Disentangling primer interactions improves SARS-CoV-2 genome sequencing by multiplex tiling PCR
Since December 2019, the coronavirus illness 2019 (COVID-19) brought on by a novel coronavirus SARS-CoV-2 has quickly unfold to nearly each nation on this planet. Quickly after the pandemic was acknowledged by epidemiologists, a bunch of biologists comprising the ARTIC Community, has devised a multiplexed polymerase chain response (PCR) protocol and primer set for focused whole-genome amplification of SARS-CoV-2.
The ARTIC primer set amplifies 98 amplicons, that are separated solely in two PCRs, throughout a virtually complete viral genome. The unique primer set and protocol confirmed a reasonably small amplification bias when scientific samples with comparatively excessive viral hundreds had been used.
Nonetheless, as pattern’s viral load turn into low, speedy lower in abundances of a number of amplicons had been seen. On this report, we’ll present that dimer formations between some primers are the key explanation for protection bias within the multiplex PCR. Based mostly on this, we suggest 12 different primers in whole within the ARTIC primer set that had been predicted to be concerned in 14 primer interactions.
The ensuing primer set, model N1 (NIID-1), displays improved general protection in comparison with the ARTIC Community’s unique (V1) and modified (V3) primer set.
![]() RLIM Polyclonal Antibody |
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29447-50ul | SAB | 50ul | EUR 187 |
![]() RLIM siRNA |
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20-abx931585 | Abbexa |
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![]() RLIM siRNA |
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20-abx931586 | Abbexa |
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![]() RLIM Polyclonal Conjugated Antibody |
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C29447 | SAB | 100ul | EUR 397 |
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DF12723-BP | Affbiotech | 1mg | EUR 195 |
![]() RLIM Rabbit pAb |
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A15837-100ul | Abclonal | 100 ul | EUR 308 |
![]() RLIM Rabbit pAb |
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A15837-200ul | Abclonal | 200 ul | EUR 459 |
![]() RLIM Rabbit pAb |
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A15837-20ul | Abclonal | 20 ul | EUR 183 |
![]() RLIM Rabbit pAb |
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A15837-50ul | Abclonal | 50 ul | EUR 223 |
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ELI-52811m | Lifescience Market | 96 Tests | EUR 865 |
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ELI-40904h | Lifescience Market | 96 Tests | EUR 824 |
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GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
![]() Polyclonal Goat anti-GST μ-form |
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GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
![]() Polyclonal Goat anti-GST p-form |
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GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
![]() RLIM ELISA KIT|Human |
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EF002487 | Lifescience Market | 96 Tests | EUR 689 |
![]() RLIM Recombinant Protein (Human) |
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RP026497 | ABM | 100 ug | Ask for price |
![]() RLIM Recombinant Protein (Mouse) |
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RP168323 | ABM | 100 ug | Ask for price |
![]() RLIM Recombinant Protein (Rat) |
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RP226193 | ABM | 100 ug | Ask for price |
![]() Mouse RLIM shRNA Plasmid |
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20-abx972467 | Abbexa |
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![]() Human RLIM shRNA Plasmid |
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20-abx959551 | Abbexa |
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![]() Rlim ORF Vector (Rat) (pORF) |
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ORF075399 | ABM | 1.0 ug DNA | EUR 506 |
![]() RLIM ORF Vector (Human) (pORF) |
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ORF008833 | ABM | 1.0 ug DNA | EUR 95 |
![]() Rlim ORF Vector (Mouse) (pORF) |
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ORF056109 | ABM | 1.0 ug DNA | EUR 506 |
![]() Rlim sgRNA CRISPR Lentivector set (Mouse) |
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K5023801 | ABM | 3 x 1.0 ug | EUR 339 |
![]() Rlim sgRNA CRISPR Lentivector set (Rat) |
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K6457601 | ABM | 3 x 1.0 ug | EUR 339 |
![]() RLIM sgRNA CRISPR Lentivector set (Human) |
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K1827101 | ABM | 3 x 1.0 ug | EUR 339 |
![]() Ring Finger Protein, Lim Domain Interacting (RLIM) Antibody |
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20-abx115301 | Abbexa |
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![]() Ring Finger Protein, LIM Domain Interacting (RLIM) Antibody |
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abx237320-100ug | Abbexa | 100 ug | EUR 509 |
![]() RLIM 3'UTR Luciferase Stable Cell Line |
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TU019947 | ABM | 1.0 ml | EUR 4617 |
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TU117914 | ABM | 1.0 ml | Ask for price |
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TU167914 | ABM | 1.0 ml | Ask for price |
![]() Rlim 3'UTR Luciferase Stable Cell Line |
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TU219467 | ABM | 1.0 ml | Ask for price |
![]() Rlim 3'UTR GFP Stable Cell Line |
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TU269467 | ABM | 1.0 ml | Ask for price |
![]() RLIM 3'UTR GFP Stable Cell Line |
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TU069947 | ABM | 1.0 ml | EUR 4617 |
![]() RLIM Protein Vector (Rat) (pPB-C-His) |
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PV301594 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Rat) (pPB-N-His) |
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PV301595 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Rat) (pPM-C-HA) |
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PV301596 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Rat) (pPM-C-His) |
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PV301597 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Human) (pPB-C-His) |
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PV035329 | ABM | 500 ng | EUR 329 |
![]() RLIM Protein Vector (Human) (pPB-N-His) |
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PV035330 | ABM | 500 ng | EUR 329 |
![]() RLIM Protein Vector (Human) (pPM-C-HA) |
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PV035331 | ABM | 500 ng | EUR 329 |
![]() RLIM Protein Vector (Human) (pPM-C-His) |
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PV035332 | ABM | 500 ng | EUR 329 |
![]() RLIM Protein Vector (Mouse) (pPB-C-His) |
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PV224434 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Mouse) (pPB-N-His) |
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PV224435 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Mouse) (pPM-C-HA) |
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PV224436 | ABM | 500 ng | EUR 603 |
![]() RLIM Protein Vector (Mouse) (pPM-C-His) |
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PV224437 | ABM | 500 ng | EUR 603 |
![]() Rlim sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K5023802 | ABM | 1.0 ug DNA | EUR 154 |
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K5023803 | ABM | 1.0 ug DNA | EUR 154 |
![]() Rlim sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K5023804 | ABM | 1.0 ug DNA | EUR 154 |
![]() Rlim sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6457602 | ABM | 1.0 ug DNA | EUR 154 |
![]() Rlim sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6457603 | ABM | 1.0 ug DNA | EUR 154 |
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K6457604 | ABM | 1.0 ug DNA | EUR 154 |
![]() RLIM sgRNA CRISPR Lentivector (Human) (Target 1) |
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K1827102 | ABM | 1.0 ug DNA | EUR 154 |
![]() RLIM sgRNA CRISPR Lentivector (Human) (Target 2) |
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K1827103 | ABM | 1.0 ug DNA | EUR 154 |
![]() RLIM sgRNA CRISPR Lentivector (Human) (Target 3) |
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K1827104 | ABM | 1.0 ug DNA | EUR 154 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
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K5023805 | ABM | 3 x 1.0 ug | EUR 376 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
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K6457605 | ABM | 3 x 1.0 ug | EUR 376 |
![]() RLIM sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
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K1827105 | ABM | 3 x 1.0 ug | EUR 376 |
![]() Human Ring Finger Protein, LIM Domain Interacting (RLIM) ELISA Kit |
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abx382827-96tests | Abbexa | 96 tests | EUR 911 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
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K5023806 | ABM | 1.0 ug DNA | EUR 167 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
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K5023807 | ABM | 1.0 ug DNA | EUR 167 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
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K5023808 | ABM | 1.0 ug DNA | EUR 167 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
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K6457606 | ABM | 1.0 ug DNA | EUR 167 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
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K6457607 | ABM | 1.0 ug DNA | EUR 167 |
![]() Rlim sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
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K6457608 | ABM | 1.0 ug DNA | EUR 167 |
![]() RLIM sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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K1827106 | ABM | 1.0 ug DNA | EUR 167 |
![]() RLIM sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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K1827107 | ABM | 1.0 ug DNA | EUR 167 |
![]() RLIM sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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K1827108 | ABM | 1.0 ug DNA | EUR 167 |
![]() Anti-Anti-SEPT6 antibody antibody |
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STJ11100949 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
![]() Anti-Anti-SEPT9 Antibody antibody |
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STJ111369 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. |
![]() Anti-Anti-SEPT11 Antibody antibody |
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STJ111530 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT4 Antibody antibody |
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STJ112276 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
![]() Anti-Anti-MARCH9 Antibody antibody |
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STJ112609 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT2 Antibody antibody |
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STJ25475 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT5 Antibody antibody |
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STJ25477 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
![]() Anti-Anti-SEPT8 Antibody antibody |
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STJ25479 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
![]() Anti-Anti-SEPT2 Antibody antibody |
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STJ28365 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT7 Antibody antibody |
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STJ28963 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
![]() Anti-Anti-SEPT7 Antibody antibody |
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STJ116214 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
![]() Anti-Anti-SEPT8 Antibody antibody |
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STJ117206 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
![]() Anti-Anti-SEPT12 Antibody antibody |
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STJ117759 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
![]() Anti-Anti-MARCH6 Antibody antibody |
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STJ118549 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-MARCH6 Antibody antibody |
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STJ118550 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-MARCH7 Antibody antibody |
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STJ118752 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT3 Antibody antibody |
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STJ118990 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT1 antibody antibody |
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STJ119580 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
![]() Anti-Anti-SEPT11 Antibody antibody |
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STJ113941 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT11 Antibody antibody |
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STJ114081 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-SEPT5 Antibody antibody |
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STJ114819 | St John's Laboratory | 100 µl | EUR 277 |
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
![]() Anti-Anti-MARCH8 Antibody antibody |
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STJ114828 | St John's Laboratory | 100 µl | EUR 277 |
![]() Anti-Anti-DDB1 Antibody |
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A00333 | BosterBio | 100uL | EUR 455 |
Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse. |
![]() Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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AEA465Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5647.8 |
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
![]() Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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AEA465Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 552.76 |
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
![]() Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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AEA465Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 746.8 |
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
![]() Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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AEA465Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3060.6 |
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
![]() Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
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4-AEA465Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
![]() ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody) |
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ELK8071 | ELK Biotech | 1 plate of 96 wells | EUR 432 |
Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
![]() Anti- ZNF660 antibody |
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ABD2410 | Lifescience Market | 100 ug | EUR 438 |
![]() Anti-STAT5B Antibody |
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A1753-100 | Biovision | EUR 479 |
![]() Anti-CREB1 Antibody |
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A1754-100 | Biovision | EUR 479 |
![]() Anti-COX7B Antibody |
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A1756-100 | Biovision | EUR 479 |
![]() Anti-COX6B1 Antibody |
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A1757-100 | Biovision | EUR 479 |
![]() Anti-COX7B2 Antibody |
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A1758-100 | Biovision | EUR 479 |
![]() Anti-COX19 Antibody |
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A1759-100 | Biovision | EUR 479 |
![]() Anti-AIMP2 Antibody |
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A1760-100 | Biovision | EUR 479 |
![]() Anti-NFKBIE Antibody |
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A1762-100 | Biovision | EUR 479 |
![]() Anti-NFKBID Antibody |
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A1764-100 | Biovision | EUR 479 |
![]() Anti-APIP Antibody |
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A1766-100 | Biovision | EUR 479 |
![]() Anti-BAG1 Antibody |
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A1768-100 | Biovision | EUR 479 |
![]() Anti-IL10RA Antibody |
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A1770-100 | Biovision | EUR 479 |
![]() Anti-IL10RB Antibody |
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A1771-100 | Biovision | EUR 479 |
![]() Anti-IL12RB1 Antibody |
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A1772-100 | Biovision | EUR 479 |
![]() Anti-IL13RA1 Antibody |
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A1773-100 | Biovision | EUR 479 |
![]() Anti-IL13RA2 Antibody |
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A1774-100 | Biovision | EUR 479 |
![]() Anti-IL17RC Antibody |
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A1775-100 | Biovision | EUR 479 |
![]() Anti-IL18R1 Antibody |
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A1776-100 | Biovision | EUR 479 |
![]() Anti-IL1R1 Antibody |
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A1777-100 | Biovision | EUR 479 |
![]() Anti- TauD Antibody |
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A1804-100 | Biovision | EUR 370 |
![]() Anti- TauD Antibody |
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A1804-30T | Biovision | EUR 146 |
![]() Anti-KRT20 Antibody |
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A1859-100 | Biovision | EUR 403 |
![]() Anti-PGR Antibody |
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A1860-100 | Biovision | EUR 403 |
![]() Anti-HSPA9 Antibody |
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A1861-100 | Biovision | EUR 403 |
![]() Anti-ERBB4 Antibody |
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A1862-100 | Biovision | EUR 403 |
![]() Anti-CA12 Antibody |
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A1865-100 | Biovision | EUR 403 |
![]() Anti-TPD52 Antibody |
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A1867-100 | Biovision | EUR 403 |
![]() Anti-STRADA Antibody |
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A1868-100 | Biovision | EUR 403 |
![]() Anti-CD276 Antibody |
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A1869-100 | Biovision | EUR 403 |
![]() Anti-ICT1 Antibody |
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A1872-100 | Biovision | EUR 403 |
![]() Anti-OCIAD1 Antibody |
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A1873-100 | Biovision | EUR 403 |
![]() Anti-BRINP1 Antibody |
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A1874-100 | Biovision | EUR 403 |
![]() Anti-WT1 Antibody |
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A1875-100 | Biovision | EUR 403 |
![]() Anti-SART3 Antibody |
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A1879-100 | Biovision | EUR 403 |
![]() Anti-RRBP1 Antibody |
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A1880-100 | Biovision | EUR 403 |
![]() Anti-KIAA1524 Antibody |
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A1881-100 | Biovision | EUR 403 |
![]() Anti-ENO2 Antibody |
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A1883-100 | Biovision | EUR 403 |
![]() Anti-GPC3 Antibody |
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A1884-100 | Biovision | EUR 403 |
![]() Anti-ACP1 Antibody |
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A1885-100 | Biovision | EUR 403 |
![]() Anti-Elafin Antibody |
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A1887-100 | Biovision | EUR 403 |
![]() Anti-AVEN Antibody |
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A1891-100 | Biovision | EUR 403 |
![]() Anti-MST1 Antibody |
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A1895-100 | Biovision | EUR 403 |
![]() Anti-WSB2 Antibody |
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A1896-100 | Biovision | EUR 403 |
![]() Anti-UPP1 Antibody |
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A1898-100 | Biovision | EUR 403 |
![]() Anti-YY1AP1 Antibody |
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A1899-100 | Biovision | EUR 403 |
Acyclovir-induced neurotoxicity with a constructive cerebrospinal fluid varicella zoster PCR outcome making a administration dilemma: a case report
Background: Varicella zoster virus central nervous system infections can current as aseptic meningitis, encephalitis, myelitis, and vasculopathy. Analysis is predicated on identification of varicella zoster virus deoxyribonucleic acid (DNA) within the cerebrospinal fluid by polymerase chain response. Remedy for these infections is acyclovir or valacyclovir.
Nonetheless, acyclovir can have neurotoxic results that may mimic the presentation of varicella zoster virus central nervous system illness. We current a uncommon presentation of a affected person who had acyclovir-induced neurotoxicity who additionally had a false-positive cerebrospinal fluid varicella zoster virus polymerase chain response outcome, making a administration dilemma.
We evaluate the scientific traits of acyclovir-induced neurotoxicity. As well as, we current the diagnostic traits of the cerebrospinal fluid viral polymerase chain response and different strategies to diagnose central nervous system varicella zoster virus illness.
Case presentation: A 68-year-old Hispanic man with end-stage renal illness was recognized with cutaneous zoster at an outdoor facility and was began on acyclovir four days previous to admission. His household famous worsening confusion, agitation, speech issue, and hallucinations, main them to carry him to the emergency division.
His cerebrospinal fluid varicella zoster virus polymerase
chain response outcome was constructive, indicating the presence of varicella zoster virus deoxyribonucleic acid within the cerebrospinal fluid; nonetheless, he didn’t have cerebrospinal fluid pleocytosis typical of varicella zoster virus meningoencephalitis.
Pharmacy information from the surface hospital revealed supratherapeutic acyclovir dosing. This led to a diagnostic dilemma over whether or not this affected person had varicella zoster virus encephalitis or acyclovir-induced neurotoxicity. Acyclovir was discontinued, and the affected person underwent two periods of hemodialysis to take away acyclovir, which led to a full neurologic restoration.
Conclusions: Varicella zoster virus encephalitis and acyclovir-induced neurotoxicity can have comparable displays. Varicella zoster virus deoxyribonucleic acid will be current within the cerebrospinal fluid throughout lively cutaneous zoster within the absence of central nervous system illness. If concern for central nervous system varicella zoster virus illness stays excessive, further testing with cerebrospinal fluid serology will be carried out.
In contrast with central nervous system varicella zoster virus illness, acyclovir-induced neurotoxicity has a extra predictable scientific decision as soon as drug remedy is discontinued or the affected person undergoes hemodialysis, which might support in making the prognosis. Clinicians ought to pay attention to this uncommon and harmful complication of acyclovir.
As well as, clinicians ought to have an understanding of the diagnostic limitations of cerebrospinal fluid viral polymerase chain response and have different approaches out there to diagnose central nervous system varicella zoster virus illness when it’s suspected.
![]() eNOS Blocking Peptide |
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AF0096-BP | Affbiotech | 1mg | EUR 195 |
![]() HSF1 Blocking Peptide |
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AF0098-BP | Affbiotech | 1mg | EUR 195 |
![]() TTK Blocking Peptide |
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AF0102-BP | Affbiotech | 1mg | EUR 195 |
![]() FRS2 Blocking Peptide |
|||
AF0103-BP | Affbiotech | 1mg | EUR 195 |
![]() Gab2 Blocking Peptide |
|||
AF0106-BP | Affbiotech | 1mg | EUR 195 |
![]() APLF Blocking Peptide |
|||
AF0108-BP | Affbiotech | 1mg | EUR 195 |
![]() RAD17 Blocking Peptide |
|||
AF0110-BP | Affbiotech | 1mg | EUR 195 |
![]() RON Blocking Peptide |
|||
AF0111-BP | Affbiotech | 1mg | EUR 195 |
![]() APAF1 Blocking Peptide |
|||
AF0117-BP | Affbiotech | 1mg | EUR 195 |
![]() ARC Blocking Peptide |
|||
AF0118-BP | Affbiotech | 1mg | EUR 195 |
![]() Bak Blocking Peptide |
|||
AF0119-BP | Affbiotech | 1mg | EUR 195 |
![]() Bax Blocking Peptide |
|||
AF0120-BP | Affbiotech | 1mg | EUR 195 |
![]() BIM Blocking Peptide |
|||
AF0121-BP | Affbiotech | 1mg | EUR 195 |
![]() CARD6 Blocking Peptide |
|||
AF0123-BP | Affbiotech | 1mg | EUR 195 |
![]() Fos Blocking Peptide |
|||
AF0132-BP | Affbiotech | 1mg | EUR 195 |
![]() Cox1 Blocking Peptide |
|||
AF0138-BP | Affbiotech | 1mg | EUR 195 |
![]() Desmin Blocking Peptide |
|||
AF0147-BP | Affbiotech | 1mg | EUR 195 |
![]() TFDP1 Blocking Peptide |
|||
AF0149-BP | Affbiotech | 1mg | EUR 195 |
![]() Dysferlin Blocking Peptide |
|||
AF0150-BP | Affbiotech | 1mg | EUR 195 |
![]() E2F4 Blocking Peptide |
|||
AF0151-BP | Affbiotech | 1mg | EUR 195 |
![]() E2F6 Blocking Peptide |
|||
AF0152-BP | Affbiotech | 1mg | EUR 195 |
![]() ERCC1 Blocking Peptide |
|||
AF0154-BP | Affbiotech | 1mg | EUR 195 |
![]() FASL Blocking Peptide |
|||
AF0157-BP | Affbiotech | 1mg | EUR 195 |
![]() FGFR2 Blocking Peptide |
|||
AF0159-BP | Affbiotech | 1mg | EUR 195 |
![]() FGFR3 Blocking Peptide |
|||
AF0160-BP | Affbiotech | 1mg | EUR 195 |
![]() FLI1 Blocking Peptide |
|||
AF0161-BP | Affbiotech | 1mg | EUR 195 |
![]() GABBR1 Blocking Peptide |
|||
AF0162-BP | Affbiotech | 1mg | EUR 195 |
![]() GAD1 Blocking Peptide |
|||
AF0163-BP | Affbiotech | 1mg | EUR 195 |
![]() GANP Blocking Peptide |
|||
AF0165-BP | Affbiotech | 1mg | EUR 195 |
![]() mGluR4 Blocking Peptide |
|||
AF0168-BP | Affbiotech | 1mg | EUR 195 |
![]() GluR5 Blocking Peptide |
|||
AF0169-BP | Affbiotech | 1mg | EUR 195 |
![]() mGluR6 Blocking Peptide |
|||
AF0170-BP | Affbiotech | 1mg | EUR 195 |
![]() mGluR7 Blocking Peptide |
|||
AF0171-BP | Affbiotech | 1mg | EUR 195 |
![]() mGluR8 Blocking Peptide |
|||
AF0172-BP | Affbiotech | 1mg | EUR 195 |
![]() GLUT1 Blocking Peptide |
|||
AF0173-BP | Affbiotech | 1mg | EUR 195 |
![]() GLUT3 Blocking Peptide |
|||
AF0174-BP | Affbiotech | 1mg | EUR 195 |
![]() GRP75 Blocking Peptide |
|||
AF0176-BP | Affbiotech | 1mg | EUR 195 |
![]() HDAC1 Blocking Peptide |
|||
AF0178-BP | Affbiotech | 1mg | EUR 195 |
![]() HDAC10 Blocking Peptide |
|||
AF0179-BP | Affbiotech | 1mg | EUR 195 |
![]() HDAC7 Blocking Peptide |
|||
AF0180-BP | Affbiotech | 1mg | EUR 195 |
![]() HDAC9 Blocking Peptide |
|||
AF0181-BP | Affbiotech | 1mg | EUR 195 |
![]() HSP10 Blocking Peptide |
|||
AF0183-BP | Affbiotech | 1mg | EUR 195 |
![]() HSP60 Blocking Peptide |
|||
AF0184-BP | Affbiotech | 1mg | EUR 195 |
![]() Involucrin Blocking Peptide |
|||
AF0186-BP | Affbiotech | 1mg | EUR 195 |
![]() COPS3 Blocking Peptide |
|||
AF0187-BP | Affbiotech | 1mg | EUR 195 |
![]() JM4 Blocking Peptide |
|||
AF0188-BP | Affbiotech | 1mg | EUR 195 |
![]() Ki67 Blocking Peptide |
|||
AF0198-BP | Affbiotech | 1mg | EUR 195 |
![]() iNOS Blocking Peptide |
|||
AF0199-BP | Affbiotech | 1mg | EUR 195 |
![]() Ku80 Blocking Peptide |
|||
AF0200-BP | Affbiotech | 1mg | EUR 195 |
![]() Ku70 Blocking Peptide |
|||
AF0201-BP | Affbiotech | 1mg | EUR 195 |
![]() Mammaglobin Blocking Peptide |
|||
AF0202-BP | Affbiotech | 1mg | EUR 195 |
![]() MLANA Blocking Peptide |
|||
AF0204-BP | Affbiotech | 1mg | EUR 195 |
![]() MCL1 Blocking Peptide |
|||
AF0205-BP | Affbiotech | 1mg | EUR 195 |
![]() MCM2 Blocking Peptide |
|||
AF0206-BP | Affbiotech | 1mg | EUR 195 |
![]() MCM5 Blocking Peptide |
|||
AF0207-BP | Affbiotech | 1mg | EUR 195 |
![]() MDM2 Blocking Peptide |
|||
AF0208-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP1 Blocking Peptide |
|||
AF0209-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP11 Blocking Peptide |
|||
AF0211-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP14 Blocking Peptide |
|||
AF0212-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP15 Blocking Peptide |
|||
AF0213-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP16 Blocking Peptide |
|||
AF0214-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP19 Blocking Peptide |
|||
AF0215-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP23 Blocking Peptide |
|||
AF0216-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP3 Blocking Peptide |
|||
AF0217-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP7 Blocking Peptide |
|||
AF0218-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP8 Blocking Peptide |
|||
AF0219-BP | Affbiotech | 1mg | EUR 195 |
![]() MMP9 Blocking Peptide |
|||
AF0220-BP | Affbiotech | 1mg | EUR 195 |
![]() NKX3.1 Blocking Peptide |
|||
AF0221-BP | Affbiotech | 1mg | EUR 195 |
![]() NM23 Blocking Peptide |
|||
AF0222-BP | Affbiotech | 1mg | EUR 195 |
![]() NSE Blocking Peptide |
|||
AF0223-BP | Affbiotech | 1mg | EUR 195 |
![]() OCT1 Blocking Peptide |
|||
AF0224-BP | Affbiotech | 1mg | EUR 195 |
![]() OCT2 Blocking Peptide |
|||
AF0225-BP | Affbiotech | 1mg | EUR 195 |
![]() OCT3 Blocking Peptide |
|||
AF0226-BP | Affbiotech | 1mg | EUR 195 |
![]() Osteopontin Blocking Peptide |
|||
AF0227-BP | Affbiotech | 1mg | EUR 195 |
![]() PCAF Blocking Peptide |
|||
AF0231-BP | Affbiotech | 1mg | EUR 195 |
![]() p63 Blocking Peptide |
|||
AF0233-BP | Affbiotech | 1mg | EUR 195 |
![]() Parkin Blocking Peptide |
|||
AF0235-BP | Affbiotech | 1mg | EUR 195 |
![]() Patched Blocking Peptide |
|||
AF0237-BP | Affbiotech | 1mg | EUR 195 |
![]() PCNA Blocking Peptide |
|||
AF0239-BP | Affbiotech | 1mg | EUR 195 |
![]() PDGFB Blocking Peptide |
|||
AF0240-BP | Affbiotech | 1mg | EUR 195 |
![]() PDGFRalpha Blocking Peptide |
|||
AF0241-BP | Affbiotech | 1mg | EUR 195 |
![]() Peripherin Blocking Peptide |
|||
AF0242-BP | Affbiotech | 1mg | EUR 195 |
![]() PGP9.5 Blocking Peptide |
|||
AF0243-BP | Affbiotech | 1mg | EUR 195 |
![]() KCNC2 Blocking Peptide |
|||
AF0244-BP | Affbiotech | 1mg | EUR 195 |
![]() KLK3 Blocking Peptide |
|||
AF0246-BP | Affbiotech | 1mg | EUR 195 |
![]() RCBTB1 Blocking Peptide |
|||
AF0248-BP | Affbiotech | 1mg | EUR 195 |
![]() RIT1 Blocking Peptide |
|||
AF0250-BP | Affbiotech | 1mg | EUR 195 |
![]() SHIP1 Blocking Peptide |
|||
AF0252-BP | Affbiotech | 1mg | EUR 195 |
![]() SHPS1 Blocking Peptide |
|||
AF0253-BP | Affbiotech | 1mg | EUR 195 |
![]() SNAP25 Blocking Peptide |
|||
AF0254-BP | Affbiotech | 1mg | EUR 195 |
![]() CSTB Blocking Peptide |
|||
AF0256-BP | Affbiotech | 1mg | EUR 195 |
![]() Synaptophysin Blocking Peptide |
|||
AF0257-BP | Affbiotech | 1mg | EUR 195 |
![]() TGFR2 Blocking Peptide |
|||
AF0259-BP | Affbiotech | 1mg | EUR 195 |
![]() TGFB3 Blocking Peptide |
|||
AF0261-BP | Affbiotech | 1mg | EUR 195 |
![]() TIMP2 Blocking Peptide |
|||
AF0264-BP | Affbiotech | 1mg | EUR 195 |
![]() TIMP3 Blocking Peptide |
|||
AF0265-BP | Affbiotech | 1mg | EUR 195 |
![]() AOS1 Blocking Peptide |
|||
AF0266-BP | Affbiotech | 1mg | EUR 195 |
![]() CDK7 Blocking Peptide |
|||
AF0267-BP | Affbiotech | 1mg | EUR 195 |
![]() EDD Blocking Peptide |
|||
AF0268-BP | Affbiotech | 1mg | EUR 195 |
![]() HAT Blocking Peptide |
|||
AF0269-BP | Affbiotech | 1mg | EUR 195 |
![]() NCoR1 Blocking Peptide |
|||
AF0270-BP | Affbiotech | 1mg | EUR 195 |
![]() NEDD8 Blocking Peptide |
|||
AF0271-BP | Affbiotech | 1mg | EUR 195 |
![]() NYREN18 Blocking Peptide |
|||
AF0272-BP | Affbiotech | 1mg | EUR 195 |
![]() PIAS2 Blocking Peptide |
|||
AF0273-BP | Affbiotech | 1mg | EUR 195 |
![]() PIAS3 Blocking Peptide |
|||
AF0274-BP | Affbiotech | 1mg | EUR 195 |
![]() SENP1 Blocking Peptide |
|||
AF0275-BP | Affbiotech | 1mg | EUR 195 |
![]() SENP5 Blocking Peptide |
|||
AF0276-BP | Affbiotech | 1mg | EUR 195 |
![]() SENP6 Blocking Peptide |
|||
AF0277-BP | Affbiotech | 1mg | EUR 195 |
![]() SENP7 Blocking Peptide |
|||
AF0278-BP | Affbiotech | 1mg | EUR 195 |
![]() SENP8 Blocking Peptide |
|||
AF0279-BP | Affbiotech | 1mg | EUR 195 |
![]() Sumo1 Blocking Peptide |
|||
AF0280-BP | Affbiotech | 1mg | EUR 195 |
![]() TIMP4 Blocking Peptide |
|||
AF0281-BP | Affbiotech | 1mg | EUR 195 |
![]() TNFR1 Blocking Peptide |
|||
AF0282-BP | Affbiotech | 1mg | EUR 195 |